This drug may cause you to dizzy or drowsy or blur your eyesight. Alcoholic beverages or cannabis (cannabis) will make you a lot more dizzy or drowsy.
Postmarketing instances of respiratory depression, such as fatalities are actually claimed with utilization of promethazine in pediatric patients.
Promethazine Symptoms and signs and symptoms of overdosage with promethazine vary from delicate depression in the central anxious method and cardiovascular technique to profound hypotension, respiratory melancholy, unconsciousness and unexpected Demise.
Promethazine is broadly dispersed in overall body tissues. Promethazine has large protein binding with about eighty to 93% of promethazine sure to plasma proteins. Promethazine passes the blood brain barrier plus the placental barrier.
Due to related pharmacologic properties, it really is sensible to anticipate identical chance with concomitant usage of opioid cough remedies and benzodiazepines, other CNS depressants, or Alcoholic beverages.
Excessively substantial dosages of antihistamines, like promethazine hydrochloride, in pediatric patients may perhaps bring about sudden Loss of life (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric clients. In pediatric individuals who will be acutely sick linked with dehydration, There's an elevated susceptibility to dystonias with the use of here promethazine HCl.
A monoamine oxidase inhibitor (MAOI) within the past two weeks, which is a medication ordinarily used for melancholy or Parkinson’s ailment
In Females with typical codeine metabolism (typical CYP2D6 activity), the level of codeine secreted into human milk is very low and dose-dependent. There isn't a information on the effects of your codeine on milk manufacturing.
A pharmacist can suggest an proper measuring system and can provide Guidelines for measuring the right dose.
If this SPL consists of inactivated NDCs stated with the FDA initiated compliance motion, they will be specified therefore.
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Daily life-threatening respiratory problems (respiratory depression). Promethazine Hydrochloride and Codeine Phosphate Oral Answer might cause respiratory problems (respiratory depression) which will occur at any time in the course check here of cure and can result in Loss of life. Your hazard of breathing problems is best when you 1st start out having Promethazine Hydrochloride and Codeine website Phosphate Oral Remedy, are taking other medicines that can result in breathing difficulties, have particular lung issues, are aged or have sure other health issues.
Codeine Codeine is undoubtedly an opioid agonist rather selective with the mu-opioid receptor, but with a A lot weaker affinity than morphine. The analgesic and antitussive Qualities of codeine get more info are already speculated to originate from its conversion to morphine.
No proof of tumorigenicity was observed in male and female mice at codeine dietary doses up to four hundred mg/kg/day (approximately reminiscent of 45 times the MRHD over a mg/m2 foundation).